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Concomitant thiazolidinediones (TZDs) may cause fluid retention and heart failure; consider dose reduction or discontinue TZDs. Potentiated by salicylates, MAOIs, alcohol, sulfa drugs, some ACE inhibitors, drugs that inhibit pancreatic function (eg, octreotide), oral hypoglycemic agents, anabolic steroids, quinine, quinidine, alpha-adrenergic blocking agents. Antagonized by corticosteroids, isoniazid, niacin, thiazides, phenothiazines, sympathomimetics, oral contraceptives, thyroid hormones, growth hormone, diazoxide, asparaginase, nicotinic acid. Variable effects with β-blockers, clonidine, lithium salts, alcohol.