Aldosterone is the main mineralcorticoid and is produced in the adrenal glands. It plays a critical role in maintaining normal plasma concentrations of sodium; patients with 21-hydroxylase deficiency can suffer hypertension and dehydration, which can lead to shock or death. Increases in the levels of the androgens (testosterone, for example) resulting from the overproduction of progesterone and 17 -hydroxy-progesterone lead to the virilization ((masculinization) of those affected. In girls, masculinization of the external genitalia is usually evident at birth. Boys appear normal at birth but sexual precocity soon follows. Accelerated growth and early bone development leads to a shortened stature.
Help I have a friend who is a gym goer Im not sure of his quantity or how long he has been taking steroids, but stopped recently because he had really bad neck pain. No dr or scan, ultrasound etc showed anything. Put on huge pain killer amounts didnt help alot but felt after about six weeks some relief. Until today when he thinks a prior knee issue has flared up. If this a result of steroid abuse how long before it heals? Im pretty sure he wont touch them again. He can handle all over aches and pains but these last two injuries have had him off work.