After intravenous administration hyoscine butylbromide is rapidly distributed (t ½α = 4 min, t ½β = 29 min) into the tissues. The volume of distribution (Vss) is 128 L (corresponding to approx. L/kg). Because of its high affinity for muscarinic receptors and nicotinic receptors, hyoscine butylbromide is mainly distributed on muscle cells of the abdominal and pelvic area as well as in the intramural ganglia of the abdominal organs. Plasma protein binding (albumin) of hyoscine butylbromide is approximately %. Animal studies demonstrate that hyoscine butylbromide does not pass the blood-brain barrier, but no clinical data to this effect is available. Hyoscine butylbromide (1 mM) has been observed to interact with the choline transport ( nM) in epithelial cells of human placenta in vitro .
Ampoules often have colored rings of paint or enamel around their necks. Color coding of modern ampoules is done during the manufacturing process. A machine paints colored rings on the ampoule shortly after it has been sealed. The rings are made of a substance that is readable by other machines. These color codes identify the substance inside the ampoule so that it does not need to be tested to verify the contents. The machine-readable color codes allow for accurate handling of the substance for the purposes of storage, labeling, and secondary packaging.