Generally, this skin rash will not disappear without treatment and can last for years. Treatment of this face skin problem is required to eliminate it. The first treatment step is to eliminate the use of products that are suspected triggers of the rash around the mouth. Oral or topical antibiotics are used and sometimes in combination with mild corticosteroid cream application to reduce redness and inflammation of the skin. Care must be taken when using the steroidal creams because they may make the mouth rash worse. The antibiotic treatment may have to be continued for up to three months. Like antibiotic treatments for other health problems, the complete treatment needs to be fully completed to eliminate the risk of perioral dermatitis reoccurring.