Nonasthmatic eosinophilic bronchitis has been increasingly identified in patients presenting to pulmonary medicine clinics. 19 – 21 Its prevalence in primary care patients with chronic cough is unknown, but probably lower. It is defined as a chronic cough in patients with normal airway hyperresponsiveness, sputum eosinophilia, and no symptoms or objective evidence of variable airflow obstruction. The presence and activation of eosinophils and metachromatic cells in the sputum differentiate nonasthmatic eosinophilic bronchitis from classic chronic bronchitis. The lack of bronchial hyperresponsiveness in nonasthmatic eosinophilic bronchitis differentiates it from asthma, because asthma also may result in the presence of reactive cells in the sputum. Patients with nonasthmatic eosinophilic bronchitis have normal spirometry and respond to inhaled and systemic corticosteroids. This condition usually can be ruled out if induced sputum contains insufficient eosinophils (less than 3 percent) or if corticosteroid therapy does not improve the cough. The condition may be transient, episodic, or persistent unless treated. 22 Rarely, patients may require long-term treatment with prednisone.
Coronary heart disease is caused by plaque buildup in the artery that provides blood and oxygen to the heart muscle. The plaque can block enough blood goin... learn more > > Edema Edema, or the abnormal accumulation of fluid in tissues in the body can be caused by several factors. Treatment of edema depends on the cause of the edema. learn more > > See the Entire Chronic Kidney Disease Topic Guide » Patient Comments & Reviews The eMedicineHealth doctors ask about Kidney Disease: Chronic Kidney Disease - Patient Experience Please describe your experience with chronic kidney disease.