Steroid genesis pathway

“You can’t poison a crucial enzyme or block an important receptor for the long-term and expect a good result.” (David Brownstein, MD [363])

The enzyme "ATP citrate lyase" is critically involved in the body's production (de novo synthesis) of cholesterol and fat (lipogenesis, involving fatty acid synthesis and triglyceride synthesis) [3,82,84,106,107] (see Fig. 7). Observed results of this biological interference by the use of garcinia cambogia weight loss pills are salient reductions in cholesterol and triglyceride levels [84,108,109].

As aforementioned, among the garcinia cambogia side effects is the suppression of the lipogenic enzyme ATP citric acid lyase by hydroxycitric acid (HCA), interfering with the production of the free form of cholesterol and fats, and optimal metabolic fuel utilization.

The freezing of internal cholesterol synthesis is a physiological worry and potentially dangerous because all vital steroid sex hormones (., pregnenolone, DHEA, progesterone, testosterone), along with bile salts and vitamin D, are made up from this base substrate –namely, LDL cholesterol, the so-called "bad cholesterol" [3,26,110] (see Fig. 7).

(Statins, cholesterol-lowering drugs, are also known to suspend the production of other essential nutrients [111], such as co-enzyme Q10 (CoQ10, ubiquinone); for more on that read my piece "Facts About Dietary Supplements: Supplement-Drug Interactions" –direct link to it at the end of this article under Recommended next pages . Since HCA-garcinia cambogia extract disrupts the enzymatic pathway of cholesterol synthesis further upstream from statins, it is quite conceivable that the diet supplement too decreases endogenous CoQ10 production –see Fig. 7.)

In terms of steroidogenesis and sexual function, statin therapy is linked to:

The rate of turnover in a metabolic pathway, otherwise known as the metabolic flux , is regulated based on the stoichiometric reaction model, the utilization rate of metabolites, and the translocation pace of molecules across the lipid bilayer . [20] The regulation methods are based on experiments involving 13C-labeling , which is then analyzed by Nuclear Magnetic Resonance (NMR) or gas chromatography-mass spectrometry (GC-MS) -derived mass compositions. The aforementioned techniques synthesize a statistical interpretation of mass distribution in proteinogenic amino acids to the catalytic activities of enzymes in a cell. [21]

Steroid genesis pathway

steroid genesis pathway


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