Steroid sulfatase deficiency symptoms

The StAR protein was first identified, characterized and named by Dr. Douglas Stocco at Texas Tech University Health Sciences Center in 1994. [18] The role of this protein in lipoid CAH was confirmed the following year in collaboration with Dr. Walter Miller at the University of California, San Francisco . [19] All of this work follows the initial observations of the appearance of this protein and its phosphorylated form coincident with factors that caused steroid production by Dr. Nanette Orme-Johnson while at Tufts University . [20]

Antibodies raised against steroid sulfatase purified from human placenta were used to follow the biosynthesis of this enzyme in human skin fibroblasts. Steroid sulfatase is synthesized as a membrane-bound M r -63 500 polypeptide with asparagine-linked oligosaccharide chains. Within 2 days, newly synthesized steroid sulfatase is processed to a mature M r -61000 form. The decrease in size is due to processing of the oligosaccharide chains, which are cleavable by endoglucosaminidase H in both the early and the mature form of steroid sulfatase. The processing involves mannosidase(s) sensitive to 1-deoxy- manno -nojirimycin. The half-life of the steroid sulfatase polypeptides is 4 days. Synthesis of steroid-sulftase-related polypeptides and steroid sulfatase activity were not detectable in fibroblasts from four patients with X-linked ichthyosis.

Steroid sulfatase deficiency symptoms

steroid sulfatase deficiency symptoms

Media:

steroid sulfatase deficiency symptomssteroid sulfatase deficiency symptomssteroid sulfatase deficiency symptomssteroid sulfatase deficiency symptomssteroid sulfatase deficiency symptoms

http://buy-steroids.org