Grape seed oil may provide some health benefit. A 1993 study supports the claim that grape seed oil increases high-density lipoprotein (HDL-C or "good cholesterol") levels and reduces LDL levels.
Although grape seeds contain antioxidants and other biologically active compounds,the cold-pressed grape seed oil contains negligible amounts due to their insolubility in instance, sufficiently high amounts of resveratrol occur in grape seed for it to be extracted commercially, yet it is almost entirely absent in the grape seed oil.
More recently, androgen receptors have been shown to have a second mode of action. As has been also found for other steroid hormone receptors such as estrogen receptors , androgen receptors can have actions that are independent of their interactions with DNA.   Androgen receptors interact with certain signal transduction proteins in the cytoplasm. Androgen binding to cytoplasmic androgen receptors can cause rapid changes in cell function independent of changes in gene transcription, such as changes in ion transport . Regulation of signal transduction pathways by cytoplasmic androgen receptors can indirectly lead to changes in gene transcription, for example, by leading to phosphorylation of other transcription factors.
In 2010, the Natural Resources Defense Council forced the FDA to review triclosan after suing them for their inaction. Because the FDA prohibited hexachlorophene , a compound similar to triclosan, Halden and others argued that the FDA should also ban triclosan.  On December 17, 2013, the FDA issued a draft rule revoking the Generally recognized as safe status of triclosan as an ingredient in hand wash products, citing the need for additional studies of its potential endrocrine and developmental effects; impact on bacterial resistance; and carcinogenic potential.