In rabbits, fetal weight reduction and cleft palate were observed at a fluticasone propionate dose approximately times the MRHDID for adults (on a mg/m² basis at a maternal subcutaneous dose of 4 mcg/kg/day). However, no teratogenic effects were reported at fluticasone propionate doses up to approximately 20 times the MRHDID for adults (on a mg/m² basis at a maternal oral dose up to 300 mcg/kg/day). No fluticasone propionate was detected in the plasma in this study, consistent with the established low bioavailability following oral administration [see CLINICAL PHARMACOLOGY ].
Recombinant vaccines are also generally more costly than traditional MLV or IA. These factors limit use of recombinant products in shelters. However, a recombinant vaccine for canine distemper (Merial) has been shown to provide rapid protection similar to standard MLV vaccines, and relatively good efficacy in the face of maternal antibody (Larson, 2006). This advantage, however, may be limited in shelters where few puppies may have maternal antibodies to distemper. In the future, attenuated products may be produced using selective deletion or vectored delivery systems with the advantages of a modified live vaccine and the safety of a killed vaccine. Stay tuned.
One of the potential downsides to seeing intranasal drug delivery achieve its real therapeutic potential (use by pay public and BLS provides in time dependent emergencies such as seizures and opiate overdose) has been the need to draw up the proper dose of a drug into a syringe. While this is a routine task for experienced medical providers, it adds a difficult step for less experienced personnel and may be just difficult enough that they prefer to use less effective methods such as rectal or buccal medications. However - that problem is easily solved if the drug is purchased prepackaged in a graduated syringe that can attach to an atomizer. The dose is easily determined by the graduations. In situations such as home use of midazolam or lorazepam for seizures where the entire volume might not be appropriate, the syringe can have a indelible mark or piece of tape applied by the clinician or pharmacy at the appropriate dosage so the parent/provider knows how much to give. Just be sure to purchase the proper dosing (concentrated).